A fact sheet about the BRCA1 and BRCA2 genes, what to do if a person tests positive for alterations in one of these genes, and consequences of genetic testing.

Hundreds of different types of mutations in these genes have been identified, some of which have been determined to be harmful, while others have no proven impact. Harmful mutations in …

BRCA1 (BReast CAncer gene 1) is a gene that, when mutated, is associated with an increased risk of several cancers including breast cancer, and, particularly, triple-negative breast cancer …

Apr 1, 2025 · When a BRCA gene is mutated, it may no longer be effective at repairing broken DNA and helping to prevent breast cancer. Because of this, people with a BRCA gene …

Inheriting damaged copies of the BRCA1 or BRCA2 genes can increase the risk for breast cancer and ovarian cancer in women and the risk for breast and prostate cancer in men, as well as …

Women who have a BRCA1 or BRCA2 (BRCA1/2) inherited gene mutation have an increased risk of breast cancer and ovarian cancer. Estimates of these risks vary greatly.

Sep 23, 2025 · Changes in these genes can raise a person’s risk for breast, ovarian, and other cancers. Learning about your family history of cancer can help you and your health care …

Without a BRCA mutation, women have about a 12% chance of developing breast cancer at some point in their life. Women with one of the BRCA mutations have about a 50%-70% chance of …

Oct 11, 2021 · Testing for BRCA mutations can help catch related cancers early. Learn more about BRCA gene mutations and cancer risk factors.

Nov 21, 2025 · Healthy BRCA1 and BRCA2 genes stop tumors from growing. But mutations in these genes may lead to breast cancer and other types of cancer. You may have heard about …